NFL Betting Odds: Weekly Point Spreads & Live Lines
Last updated: September 15, 2025 7:30 pm
If you plan on betting on pro football this season, you are going to want to visit this page often. Here you will find the live NFL odds for every one of this week’s games. That includes all of the current NFL point spreads and totals.
You can also easily view the start time “Time” and rotation number “#” for every matchup.
| Rot | Matchup | Date/Time | Open |  |  |  |  |  |  |  |  |  |  |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 279 280 | Chargers Raiders | Sep/15 10:00 PM | -3 -110 44½ -110 | -3½ -101 46½ -115 | -3 -115 47 -110 | OFF | -3 -125 46½ -110 | -3½ +100 46½ -110 | -3½ +102 46½ -108 | -3½ -101 46½ -115 | -3½ -105 46½ -110 | -3½ -105 46½ -118 | -3½ -101 46½ -115 |
| 301 302 | Dolphins Bills | Sep/18 8:15 PM | 48½ -110 -1½ -110 | 49 -115 -11½ -110 | 49½ -105 -12 -110 | OFF | 49½ -110 -13 +100 | 49½ -110 -11 -110 | 49½ -108 -12½ -108 | 49 -116 -11½ -111 | 49½ -115 -12½ -110 | 49½ -110 -12½ -115 | 49 -115 -11½ -110 |
| 451 452 | Colts Titans | Sep/21 1:00 PM | -2 -110 42½ -110 | -3 -125 43½ -110 | -3½ -105 43 -115 | OFF | -3 -120 43½ -110 | -3½ -105 43½ -110 | -3 -118 43½ -108 | -3 -125 43½ -110 | -3 -120 43½ -110 | -3 -120 43½ -110 | -3½ +100 43½ -110 |
| 453 454 | Falcons Panthers | Sep/21 1:00 PM | -2½ -110 44½ -110 | -5 -110 43½ -110 | -3 -110 44½ -110 | OFF | -5 -110 43½ -110 | -5 -110 43 -110 | -3½ -108 43½ -108 | -5 -110 43½ -110 | -5 -110 43½ -110 | -4½ -115 43½ -118 | -5 -110 43½ -110 |
| 455 456 | Raiders Commanders | Sep/21 1:00 PM | 47½ -110 -5½ -110 | 44½ -105 -3 -110 | 47 -105 -5½ -115 | OFF | OFF OFF -6 -110 | 44½ -110 -3 -110 | 47½ -108 -6 -108 | 47½ -101 -5½ -112 | 44½ -110 -3 -115 | 44½ -110 -3½ -105 | 44½ -110 -3 -110 |
| 457 458 | Packers Browns | Sep/21 1:00 PM | -7 -110 43 -110 | -8 -110 42½ -105 | -7½ -105 42 -115 | OFF | -9 +100 42 -110 | -8 -110 42 -110 | -8 -108 41½ -108 | -8 -108 42½ -105 | -8 -110 42 -110 | -8½ +100 42½ -110 | -8 -110 42½ -105 |
| 459 460 | Bengals Vikings | Sep/21 1:00 PM | 47½ -110 -1½ -110 | 41½ -110 -2½ -120 | 46½ -110 -2 -110 | OFF | 41½ -110 -3 -110 | 41 -110 -3 -105 | 42½ -108 -3½ -108 | 42½ -109 -3½ -110 | 41½ -105 -3 -105 | 41½ -105 -3 -115 | 41½ -110 -2½ -120 |
| 461 462 | Rams Eagles | Sep/21 1:00 PM | 45 -110 -4½ -110 | 44½ -110 -3½ +100 | 44 -115 -3 -120 | OFF | 44½ -110 -3 -125 | 44½ -110 -3½ +100 | 44½ -108 -3½ -108 | 44½ -109 -3½ +100 | 45 -110 -3½ -110 | 44½ -110 -3½ -110 | 44½ -110 -3 -125 |
| 463 464 | Steelers Patriots | Sep/21 1:00 PM | -1 -110 42½ -110 | -1 -105 44½ -107 | -1 -105 44½ -110 | OFF | 44½ -110 PK -110 | 44½ -110 PK -110 | 44½ -108 PK -108 | -1 -105 44½ -108 | -1 -110 44½ -110 | -1½ -105 44½ -108 | -1 -105 44½ -107 |
| 465 466 | Jets Bucs | Sep/21 1:00 PM | 44½ -110 -5½ -110 | 44½ -110 -7 -105 | 44½ -110 -4½ -110 | OFF | OFF OFF -7 +100 | 44 -110 -6½ -110 | 44½ -108 -7 -108 | 44½ -110 -5 -105 | 44½ -110 -7 -110 | 44½ -110 -7 -112 | 44½ -110 -7 -105 |
| 467 468 | Texans Jaguars | Sep/21 1:00 PM | 43 -110 -1½ -110 | 44½ -110 -1½ -110 | 44½ -110 -1½ -105 | OFF | OFF | 44½ -110 -1 -110 | 44½ -108 -1 -108 | 44½ -106 -1½ -108 | 44½ -110 -1½ -105 | 43½ -110 -1½ -102 | 44½ -110 -2 +100 |
| 469 470 | Broncos Chargers | Sep/21 4:05 PM | 43½ -110 -3 -110 | 46 -110 -2½ -120 | 45½ -115 -2½ -120 | OFF | OFF | 46 -110 -3 -105 | 45½ -108 -2½ -108 | 46 -108 -2½ -119 | 45½ -110 -2½ -115 | 45½ -110 -2½ -110 | 46 -110 -2½ -120 |
| 471 472 | Saints Seahawks | Sep/21 4:05 PM | 40½ -115 -7½ -110 | 41½ -110 -7½ -105 | 41½ -110 -7½ -105 | OFF | 41½ -110 -7 -115 | 41½ -110 -7½ -110 | 41½ -108 -7½ -108 | 41½ -109 -7½ -105 | 41½ -110 -7½ -110 | 41½ -115 -7½ -110 | 41½ -110 -7½ -105 |
| 473 474 | Cowboys Bears | Sep/21 4:25 PM | 46 -110 -1½ -110 | 50 -115 -1 -110 | 49½ -110 -1 -115 | OFF | 50 -110 -1 -110 | 50 -110 -1 -110 | 50 -108 -1½ -108 | 50 -111 -1 -112 | 50 -110 -1 -110 | 49½ -110 -1½ -108 | 50 -115 -1 -110 |
| 475 476 | Cardinals 49ers | Sep/21 4:25 PM | 42½ -115 -1½ -110 | 43½ -115 -1½ -113 | 44 -110 -1½ -115 | OFF | 44 -110 -1½ -110 | 44 -110 -1½ -110 | 43½ -108 -1 -108 | 43½ -116 -1½ -112 | 43½ -110 -1½ -110 | 43½ -110 -1½ -105 | 43½ -115 -2 +100 |
| 477 478 | Chiefs Giants | Sep/21 8:20 PM | -6½ -110 43 -110 | -6 -106 45 -110 | -6 -110 44½ -115 | OFF | -6 -110 44½ -110 | -5½ -110 44½ -110 | -6 -108 45 -108 | -6 -107 44½ -113 | -6 -105 44½ -110 | -5½ -112 44½ -110 | -6 -106 45 -110 |
| 479 480 | Lions Ravens | Sep/22 8:15 PM | 50½ -110 -6½ -110 | 51½ -110 -6 -105 | 51½ -110 -6 -110 | OFF | 51½ -110 -6 -110 | 51½ -110 -6 -110 | 51½ -108 -6 -108 | 51½ -111 -6 -106 | 51½ -110 -6 -110 | 51½ -110 -6 -108 | 51½ -110 -5½ -105 |
How to Read the NFL Odds
NFL betting odds are shown in three main formats: moneylines, point spreads, and totals (over/unders).
The moneyline is the simplest. It shows which team is favored and what the payout will be if they win outright. A favorite might be listed at -150, meaning you must risk $150 to win $100, while an underdog at +130 pays $130 on a $100 bet if they pull the upset.
The point spread is designed to level the playing field. The favorite will have to win by more than the listed number (for example, -3.5) to “cover” the spread, while underdog bettors win if their team loses by less than that margin or wins outright.
The total, or over/under, sets the expected combined score of both teams. Bettors simply choose whether the final score will go over or under that number. For example, if the line is 46.5, an outcome of 27–24 would go “over” since the total points equal 51.
Together, these three markets cover the vast majority of NFL wagers, and learning to read them is the first step to becoming a sharper bettor. We go over these in further detail and even more options in our NFL betting guide.
Why Our NFL Odds Page is Valuable
We provide lines from some of the best-known online sportsbooks in the industry as a tool to help you find the best possible line on every game. Different sportsbooks will have slightly different spreads, totals, and moneylines. By scanning our board, you can quickly see where you can get the most favorable number on each of your bets.
It also helps you track market movement. Odds shift during the week as bettors and bookmakers react to injuries, weather, and betting action. Following these changes can tell you where the sharp money is heading or when public sentiment is driving a number away from the opening line. Which is why we also provide the opening NFL point spreads and totals for every game under “Opener.”
It’s our way of showing you the importance of having options. Having multiple books available means you get the best odds when you go to place a wager. It lets you identify value spots and outlier numbers. Each half number matters, especially on the key NFL numbers, because it can turn a loss into a push or a push into a win. By monitoring the odds here, you can put yourself in a position to consistently get the best of the number.
But don’t only look at the point spreads for value. Sometimes the moneyline is mispriced according to a team’s chances of winning, and our NFL spread to money line converter can help find those opportunities.
While this page shows just individual games, we also have the current Vegas Super Bowl odds that are updated each week as well.
How to Beat the NFL Betting Lines
Beating the NFL odds on your own is a difficult task and one that takes a lot of time to master. That’s where our experts come into play. If you want to beat the books consistently, check out our premium picks for a list of all available packages.
You can also purchase plays directly from this page. In the far right column under “Picks,” you will see a link for each game. That will take you to all the current packages that include a play on that specific game.
I’ve put together a list of the top NFL handicappers to follow, but you can see what our handicappers have to offer. Each week, several experts will provide free NFL best bets against the spread or total at no cost.
Looking for advice on how to improve your handicapping skills? We have you covered as well. Our NFL handicapping guide is the ultimate resource for picking more winners.
Struggling to understand something that wasn’t mentioned? Have a question or concern about how to bet on football? I would be happy to help out in any way I can, just shoot me an email at jimmy@boydsbets.com.
More NFL Betting Odds & Lines:
